The 78C --> T (T254M) XHIM mutation: lack of a tight phenotype-genotype relationship.

undoubtedly interesting. If these transcripts represent residual disease, then the identification of the mechanism responsible for its suppression is very important. However, we again assert that, thus far, it has not been established that detection of MRD in CML by PCR can be used clinically. Until PCR testing has been standardized and proven reliable and until randomized studies have proven that treating molecular relapse is indeed beneficial for patients with CML, PCR-based results should be interpreted only within the confines of well-defined clinical trials. Consequently, any generalized guidelines for using PCR tests to guide treatment appear premature and should be viewed critically.